Hydroxychloroquine Online

Hydroxychloroquine has antimalarial properties and also has anti-inflammatory and immunosuppressive effects in chronic or systemic discoid lupus erythematosus, acute and chronic rheumatoid arthritis (RA). Its mechanism of action in malaria, lupus erythematosus, and rheumatoid arthritis is completely unknown.

Hydroxychloroquine actively suppresses asexual forms of erythrocytes, as well as gametes of R. vivax and P. malariae, which disappear into the bloodstream at the same time as asexual forms. Following oral administration, hydroxychloroquine is rapidly and almost completely absorbed. Plasma protein binding - 45%. The plasma environment changes over time after ingestion of hydroxychloroquine. In the liver, hydroxychloroquine is converted to the semi-active ethylated metabolite. Unchanged hydroxychloroquine and its metabolism are well distributed in the body.

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The toxic effect of hydroxychloroquine on the retina is highly dose-dependent. The incidence of retinopathy at doses up to 6.5 mg / kg of “ideal” body weight is low.

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Before starting long-term treatment with hydroxyl chloride both eyes should be thoroughly examined. The inspection should include determining the sharpness of the image. Color vision organ examination and visual field assessment.

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It is recommended to be careful when using hydroxychloroquine in patients with liver and kidney disease, who may need to reduce its doses, as well as in patients taking medications that can cause adverse effects on these organs.

Application in children

Contraindications for use in children when long-term treatment is needed (children are at increased risk of toxicity). Contraindications for use in children under 6 years.

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